Penicillin Cocktail: A Modern Classic That Heals with Smoke, Spice, and Citrus

Cocktail Snapshot

• Spirit Base: Blended Scotch + Islay Scotch

• Flavor Profile: Smoky, gingery, citrusy, warm

• Serve Style: Shaken, served over rocks

• Difficulty: Easy

• Invented: 2005, NYC

Backstory & Cultural Relevance

The Penicillin Cocktail was created by Sam Ross at the legendary New York speakeasy Milk & Honey in 2005. Named cheekily after the famed antibiotic, the drink’s warm ginger, sweet honey, and tart lemon combine with smoky scotch in a formula that feels medicinal — but in the most indulgent way.

Ross, also known for crafting the Paper Plane, designed this cocktail to modernize the whisky sour by introducing layered complexity through peated Islay scotch floated on top. It quickly gained cult status and is now considered a modern classic — frequently appearing on cocktail menus across the globe.

Ingredients

• 2 oz Blended Scotch (Monkey Shoulder or Famous Grouse)

• ¾ oz Fresh Lemon Juice

• ¾ oz Honey-Ginger Syrup (see below)

• ¼ oz Islay Scotch (for float – e.g., Laphroaig, Ardbeg)

• Garnish: Candied ginger or lemon twist

Honey-Ginger Syrup

Simmer equal parts honey and water with slices of fresh ginger for 10 minutes, then strain and cool.

Method

1. Combine blended scotch, lemon juice, and honey-ginger syrup in a shaker with ice.

2. Shake vigorously until well chilled (about 10–12 seconds).

3. Strain over a large rock in a chilled double Old Fashioned glass.

4. Float the Islay scotch gently over the top.

5. Garnish with a slice of candied ginger or a lemon twist.

Why It Works

The Penicillin is a study in balance and contrast:

• The ginger and lemon bring a sharp, invigorating brightness.

• The honey provides velvety smoothness and sweet depth.

• The blended scotch forms a robust foundation.

• The Islay float adds a whisper of smoke, leaving a final flourish of sophistication on the nose and finish.

Variations & Twists

• Smoky & Spicy: Add a dash of cayenne to the syrup.

• Bourbon Penicillin: Swap scotch for a bold bourbon.

• Penicillin Spritz: Lighten it up with sparkling water and serve long.

• Zero-Proof Version: Use Ritual Whiskey Alternative and ginger-honey syrup for a spirit-free cure.

Pairing Ideas

• Cheese & Charcuterie – The smoky, sweet notes pair beautifully with aged cheddar or smoky meats.

• Asian Cuisine – Ginger and citrus marry well with dishes like Thai curries or sesame noodles.

• Rainy Nights & Firesides – A blanket, a book, and a Penicillin? Instant soul salve.

Final Sip

The Penicillin cocktail is proof that a simple twist on the whisky sour can be elevated into an unforgettable experience — warming, vibrant, and smoky enough to stop time. Whether you're feeling under the weather or just craving something complex, this drink hits all the right notes.